China 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Moetsi le Feme |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Tlhaloso e Khutšoanyane:

Ponahalo	Likristale tse tšoeu ho isa ho tse tšoeu kapa phofo ea crystalline.
MF	C16H22N2O6
MW	338.36
Bohloeki	98+

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Boemo ba lipalangoang&mokhoa oa ho romella o khothalelitsoeng:
ka moya, ka lewatle kapa ka polelo

Boemo ba polokelo:
E tiisitsoe ka ho omme, Mocheso oa Kamore

Bonyane Bonyane ba Odara:
Puisano

Setifikeiti:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC e teng

Litlhaloso tse tšoanang

(S) -ethyl 2-(tert-butoxycarbonylaMino) -3-(4-nitrophenyl)propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl] -4-nitro-, ethyl ester

Ho paka ka hare

Hangata li sebelisoa ho paka phofo.'Me li ka thibela khanya ea letsatsi le metsi hore li se ke tsa senyeha.

ho phuthela ka ntle

Lebokose le thata le ka sireletsa lihlahisoa tsa hau ho senya le ho koloba.

Lisebelisoa

Nidanib, ke khemikhale.Lebitso la lik'hemik'hale 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland of methyl] - 2 - oksijene -, methyl ester, (z) - Clinically, sehlahisoa sena se sebelisetsoa ho phekola idiopathic pulmonary fibrosis (IPF).
Nidanib e ithutile bakuli ba 1,529 ba nang le idiopathic pulmonary fibrosis (IPF) litekong tse ngata tsa bongaka.Lintlha tsa polokeho tse hlahisitsoeng li thehiloe papisong ea bakuli ba 1061 ba fuoeng nidanib 150 mg habeli ka letsatsi le placebo nakong ea libeke tse 3 tsa libeke tse 52, lithuto tse laoloang ka mokhoa o sa reroang, tse sa boneng habeli, tse laoloang ke placebo (INPULSIS-1 le INPULSIS-2).Liketsahalo tse mpe ka ho fetisisa tse amanang le tšebeliso ea nidanib li ne li kenyelletsa letšollo, ho nyekeloa ke pelo le ho hlatsa, bohloko ba mpeng, ho lahleheloa ke takatso ea lijo, ho lahleheloa ke boima ba 'mele, le li-enzyme tse phahameng tsa sebete.Ka kopo sheba ho [Litlhokomelo] bakeng sa taolo ea litlamorao tse tsamaellanang le tsona.The Systematic Organ Classification (SOC) ea MedDRA e fana ka kakaretso ea karabelo e mpe le ho arola khafetsa.
Nidanib ke substrate ea P-gp (sheba Pharmacokinetics).Phuputsong e khethehileng ea litšebelisano tsa lithethefatsi, tsamaiso e kopanetsoeng ea ketoconazole, e matla ea P-gp inhibitor, e eketsehile ho pepesehela nidanib ho makhetlo a 1.61 ka sebaka se tlas'a lekhalo (AUC) le linako tsa 1.83 ka mahloriso a phahameng (Cmax).
Thutong ea tšebelisano ea lithethefatsi le rifampicin e matla ea P-gp, ho pepesetsoa nidanib ho theohile ho isa ho 50.3%, joalo ka ha ho lekantsoe ka sebaka se ka tlas'a mokokotlo (AUC), ha se kopantsoe le rifampicin bapisoa le Nidanib feela.Ka khatello e phahameng (Cmax), e theohetse ho 60.3%.
Ha e sebelisoa hammoho le sehlahisoa sena, li-inhibitors tse matla tsa P-gp (mohlala, ketoconazole kapa erythromycin) li ka eketsa ho pepeseha ha nidanib.Maemong ana, mamello ea mokuli ho nidanib e lokela ho beoa leihlo ka hloko.Taolo ea litlamorao tse mpe e kanna ea hloka ho emisoa, ho fokotsa litekanyetso, kapa ho khaotsa kalafo ka sehlahisoa sena (bona [Tšebeliso le litekanyetso]).
Li-inducers tse matla tsa P-gp (mohlala, rifampicin, carbamazepine, phenytoin le St. John's wort) li ka fokotsa ho pepeseha ha nidanib.Metsoako e meng e nang le che kapa e fokolang ea P-gp e lokela ho nkoa.

lihlahisoa tse amanang

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe (4-NO2)-OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe (4-NO2).H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

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