China 130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester Moetsi le Factory |Jiayinglai

130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester) -methyl ester

Tlhaloso e Khutšoanyane:

Ponahalo	Likristale tse tšoeu ho isa ho tse tšoeu kapa phofo ea crystalline.
MF	C12H21NO6
MW	275.3
Bohloeki	98+

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Boemo ba lipalangoang&mokhoa oa ho romella o khothalelitsoeng:
ka moya, ka lewatle kapa ka polelo

Boemo ba polokelo:
Boloka sebakeng se lefifi, se tiisitsoe moo ho omileng, Mocheso oa Kamore

Bonyane Bonyane ba Odara:
Puisano

Setifikeiti:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC e teng

Litlhaloso tse tšoanang

dimethyl(tert-butoxycarbonyl) -D-glutamate;
(R) -2-tert-Butoxycarbonylamino-pentanedioic acid dimethyl ester;
(Tert-Butoxy)Carbonyl D-Glu(OMe)-OMe (Sirapo);
Boc-D-Glu(OMe)-OMe (Sirapo);
dimethyl (2R) -2- [(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate;
Tšilafalo ea Alogliptin 43;
1,5-dimethyl (2R) -2-{[(tert-butoxy)carbonyl]amino}pentanedioate

Ho paka ka hare

Hangata li sebelisoa ho paka phofo.'Me li ka thibela khanya ea letsatsi le metsi hore li se ke tsa senyeha.

ho phuthela ka ntle

Lebokose le thata le ka sireletsa lihlahisoa tsa hau ho senya le ho koloba.

Lisebelisoa

Fluoroquinolones e na le li-antibacterial spectrum tse pharaletseng, ts'ebetso e matla ea antibacterial, karabelo e tlase e mpe, ho kenella hantle ha lisele, bioavailability e phahameng ea molomo, nako e telele ea tsamaiso le tsamaiso e bonolo.Hangata li sebelisoa ho phekola mafu a tšoaetsanoang a kang tšoaetso ea matšoafo le tšoaetso ea moroto.Sebopeho sa lithethefatsi tsa antibacterial tsa fluoroquinolone se khetholloa ke ho ba teng ha fluorine sebakeng sa botšelela sa nucleus ea motsoali oa quinolone.
Leha ho le joalo, lilemong tsa morao tjena tse 10, ka lebaka la khatello e khethehileng e hlahisoang ke ts'ebeliso e pharaletseng ea mofuta ona oa lithethefatsi, mefuta e hanyetsanang le lithethefatsi e eketseha, haholo-holo lilemong tsa morao tjena, Streptococcus pneumoniae e hanyetsanang le quinolone e na le khanyetso e fapaneng, e hanyetsanang le penicillin, lithibela-mafu tsa macrolide le lithibela-mafu tsa quinolone.Ka nako e ts'oanang, ho ile ha fumanoa hore tse ling tsa fluoroquinolones li ka etsa hore nako ea QTc e be le nako e telele ea electrocardiogram, hepatotoxicity le phototoxicity, e leng se fokotsang tšebeliso ea bona.
Bakeng sa ho hlola mefokolo e kaholimo ea fluoroquinolones, ho potlakile ho theha metsoako e mecha ea meralo e nang le ts'ebetso e ntle ea antibacterial, antibacterial spectrum le litlamorao tse nyane kamoo ho ka khonehang khahlano le libaktheria tse hanyetsanang le lithethefatsi tse ngata.Letoto la lithethefatsi tse ncha tse sa tsoa etsoa tsa fluoroquinolone-free (NFQ) tse nang le 8-methoxyl li fapane le lithibela-mafu tsa fluoroquinolone ka hore ha li na fluorine sebakeng sa 6 sa nucleus ea motsoali oa quinolone, empa li ntse li e-na le ts'ebetso e matla ea antibacterial in vitro.nemonoxacin ke NFQ e ncha e khethang baktheria topoisomerase inhibitor.
Ha ho bapisoa le fluoroquinolones hona joale 'marakeng, Nenofloxacin e emela sehlopha se secha sa lithethefatsi tsa meralo.nemonocacin (TG-873870), sethethefatsi se secha sa quinolone se ntlafalitsoeng ke Procter & Gamble (P&G), se bonts'itse ts'ebetso ea bohlokoa ea antibacterial khahlano le mefuta e fapaneng ea likokoana-hloko tse amehang tsa bongaka, ho kenyelletsa Staphylococcus aureus le Streptococcus pneumoniae e hanyetsanang le lithethefatsi.Liphello tsa teko ea litoeba tse tšoaelitsoeng li bontšitse hore phello ea antibacteria ea sehlahisoa sena e ne e le matla ho feta boholo ba li-quinolone tsa hona joale.Ntle le moo, sehlahisoa se na le thepa e ntle ea pharmacokinetic mme se mamelloa hantle.

lihlahisoa tse amanang

Fmoc-Gly-glu(otbu)-oh	Boc-D-Glu(OBzl)-Oet
HL-Glu-OH	Boc-D-Glu(Obzl)-OH
HD-Glu-OH	Boc-D-Glu(Ome)-OH
DL-Glu-OH	Boc-D-Glu(Ome)-OH.DCHA
DL-Glu-OH.H2O	Boc-Glu(OBzl)-Obzl
L-Glu(Obzl)-NCA	Boc-L-Glu-OBzl
D-Glu(Obzl)-NCA	Boc-D-Glu-Obzl
DL-Glu(Obzl)-NCA	Boc-D-Glu-Otbu-OH
L-Glu-Obzl	Boc-D-Glu(OMe)-OMe
Tos-Glu-Obzl	Boc-D-Glu(Obzl)-Obzl
L-Glu(Ome)-Obzl.TOS	Boc-L-Glu(Ome)-Ome
AC-Glu(OtBu)	Boc-L-Glu(OMe)-OH
DL-Glu(Ome)	Boc-L-Glu(OBzl)-OH
HD-Glu(OMe)-OH	Boc-Glu-Otbu
HL-Glu(OMe)-OH	Boc-L-Glu(Obzl)-Ome
L-Glu(Obzl)	Boc-L-Glu(Oet)
HL-Glu(OtBu)-OH	Fmoc-L-Glu-OH
HL-Glu(OEt)-OH	Fmoc-D-Glu-OH
L-Glu(Otbu)-Otbu-OH	Fmoc-D-Glu(Ome)-OH
HD-Glu(OBzl)-OH	Fmoc-L-Glu(OcHx)-OH
D-Glu-OBzl	Fmoc-L-Glu(OMe)-OH
HL-Glu(Ome)-Otbu.Hcl	Fmoc-L-Glu(OtBu)-OH
D-Glu(Obzl)-Otbu.HCL	Fmoc-D-Glu(OBzl)-OH
D-Glu(OtBu)-OtBu•HCl	Fmoc-D-Glu(Otbu)-OH
L-Glu(OcHx).hcl	Fmoc-L-Glu-OtBu
HL-Glu(OBzl)-OBzl.HCl	Fmoc-L-Glu(OBzl)-OH
HL-Glu-OBzl.HCl	Fmoc-L-Glu(Cbz-ee)
D-Glu(OBzl)-OBzl.HCl	Fmoc-N-Me-L-Glu(Otbu)-OH
DL-Glu(Ome)-Ome.Hcl	Fmoc-glu-obzl
HL-Glu(OtBu)-OtBu•HCl	Cbz-L-Glu-OH
HL-Glu(OMe)-OMe.HCl	Cbz-D-Glu-OH
L-Glu(Obzl)-OME.HCL	ZL-Glu-OBzl
HL-Glu(OEt)-OEt·HCl	ZD-Glu-OBzl
L-Glu(Obzl)-Otbu.HCl	Cbz-L-Glu-Otbu
HD-Glu(OMe)-OMe·HCl	Cbz-D-Glu(ome)
N-Pht-Glu	Cbz-L-Glu(OBzl)-OH
Boc-L-Glu-OH	Cbz-L-Glu(Otbu)
Boc-D-Glu-OH	Cbz-L-Glu(Ome)
Boc-Glu(obzl)-NH2	Cbz-D-Glu(OtBu)-OH
Boc-Glu (trt)-OH	Cbz-L-Glu(Ome)-OtBu
Boc-L-Glu(OcHx)-OH	Cbz-L-Glu-OBzl.DCHA
Boc-L-Glu(OtBu)-OH	Cbz-L-Glu(Oet)-OH
Boc-Glu(Osu)-Otbu	Boc-Glu-Otbu (Osu)

Boemo bo phahameng

1. Tshebeletso ya R&D e teng
2. Moetsi ea netefalitsoeng oa ISO, tiiso ea boleng
3.Tsamaiso e feletseng ea ts'ebeletso ea ho latela nakong ea tlhahiso
4.Chelete e phahameng e atlehang
5.Litokomane tsa setifikeiti sa boleng tse fanoeng ho latela kopo ea moreki
Tšebeletso ea 6.E kholo ka mor'a thekiso, ho boloka kamano e haufi le moreki
7.Mohloli o felletseng oa ho thusa ho fokotsa litšenyehelo tsa ho tsamaisa thepa
8.Free sampole e filwe ho hlahloba tsoa boleng pele ho tefo efe kapa efe
9.Ho buisanoa ka nako ea tefo
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