15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

Phofo e tšoeu ea kristale;Ha e qhibilihe ka metsing le petroleum ether, e qhibilihang ka har'a ethyl acetate le methanol;mp ke 115-116 ℃;Potoloho e khethehileng [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
E sebelisoa bakeng sa synthesis ea polypeptide, joalo ka monoma ea tšireletso ea amino acid.
O-benzyl-l-threonine e ne e emisitsoe ka tharollo ea dioxane le acylated ka tert-butylcarbonyl azide ho fumana sehlahisoa se tala, se neng se ntšoa ke ethyl acetate ka pH ea 9-10 ebe e tsosolosoa hape.
Karolo e sebetsang ea thymic oietin Ⅱ ea li-secretions tsa thymus.Thymoietin II ke motsoako o le mong oa polypeptide o arohaneng le homone ea thymus.E entsoe ka li-amino acid tse 49, 'me sekhechana sa ketane ea peptide se entsoeng ka li-amino acid tse 5 se na le mesebetsi eohle e tšoanang le ea thymoietin II.Ka hona, sekhechana sena sa pentapeptide se bitsoa thymus pentapeptide.Bosoeu bo bosoeu bo omisitsoeng boima bo hlephileng kapa phofo.
E 'ngoe ea mesebetsi ea thymus pentapeptide ke ho susumetsa karohano ea lisele tsa T.E ka khetha ka mokhoa o ikhethileng phetoho ea lisele tsa Thy-1- prothorax ho lisele tsa Thy-1+ T.Phapang ea lisele tsa T e kopanngoa le ho eketseha ha maemo a intracellular cAMP.Mosebetsi o mong oa motheo oa thymus pentapeptides ke ho tlama ho li-receptor tse itseng tsa lisele tsa T tsa mali tse hōlileng tsebong, ho eketsa boemo ba intracellular cAMP, 'me kahoo ho susumetsa letoto la liketso tsa intracellular, tseo hape e leng motheo oa ts'ebetso ea eona ea immunomodulatory.Boemong bo tloaelehileng ba 'mele, thymus pentapeptide e bonts'itse phello e matlafatsang ea' mele ea ho itšireletsa mafung, e ka eketsang sekhahla sa sebopeho sa E rosette le sekhahla sa phetoho ea splenic lymphocyte, ho ntlafatsa methati e fapaneng ea karabelo ea mantlha kapa ea bobeli ea 'mele oa ho itšireletsa mafung, le ho eketsa palo ea mofuta oa IgM le IgG kapa Lisele tsa mofuta oa IgA tse etsang li-antibody.Thymus pentapeptide e ka boela ea ntlafatsa tšebetso ea phagocytosis ea macrophages, ea eketsa tšebetso ea enzyme le phagocytosis ea polymorphonuclear neutrophils, ea eketsa litaba tsa antibody e potolohang, le ho ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung ea lisele tse khubelu tsa mali.Thymus pentapeptide e ka etsa hore lisele tse ntle tsa CD4 le CD8 li sebetse, e le hore lisele tse khethehileng tsa Tc li ka boloka bophelo bo bolelele, empa hape li ka kenya lisele tsa Th le ho etsa hore lisele tsa Ts li sebetse.Litlamorao tse thibelang tšoaetso le kalafo ea thymus pentapeptide li amana le ntlafatso ea ts'ebetso ea lisele tsa TC.Palo e loketseng ea thymus pentapeptide e ka eketsa haholo tlhahiso ea interferon ho itšireletsa mafung.Ho khothaletsa le ho khothaletsa phapang ea lisele tsa T le kholo;CD4/CD8 e ne e atisa ho ba e tloaelehileng ka ho laola karolo ea li-subsets tsa T lymphocyte;Ntlafatsa mosebetsi oa phagocytosis ea macrophages;Ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung;Eketsa tšebetso ea lisele tse bolaeang tsa tlhaho;Eketsa boemo ba tlhahiso ea interleukin-2 le polelo ea li-receptor;Ntlafatsa tlhahiso ea γ interferon liseleng tsa mali tsa peripheral mononuclear;Ntlafatsa ts'ebetso ea SOD ho serum.
E ka sebelisoa ho bakuli ba nang le hlahala e kotsi ba nang le ts'ebetso ea 'mele ea ho itšireletsa mafung ka mor'a radiotherapy le chemotherapy.Phekolo ea lefu la sebete la B;Litšebetso tse kholo tsa ho buoa le mafu a matla;mafu a autoimmune a kang ramatiki ea rumatoid, lupus erythematosus;Mofuta oa II lefu la tsoekere mellitus, lefu la ho khaotsa ho ilela khoeli;Motho ea nang le ts'ebetso ea 'mele ea ho itšireletsa mafung e fokolang.